ADHD

For further information and guidance on how to treat your patients with Medikinet^® XL (methylphenidate hydrochloride), please download and read the SPC

Medikinet^® XL ▼ (methylphenidate hydrochloride)

Medikinet^® XL can be used as part of a comprehensive treatment programme for attention deficit hyperactivity disorder (ADHD) in children aged 6 years of age and over and adults when remedial measures alone aren’t sufficient¹.

Dosing & administration in children

• At the start of treatment with Medikinet^® XL, careful dose titration is necessary
• Starting dose: 10 mg daily taken with or after breakfast¹. Medikinet XL has to be taken with or after a meal in order to obtain sufficiently prolonged action and to avoid high plasma peaks. Therefore, Medikinet XL should not be administered without food
• Maximum daily dose: 60 mg¹
• Titrate to an adequate dose then carry out a 6-week trial to determine the efficacy of the treatment for the patient²

Working with the school day

Medikinet^® XL consists of an immediate-release component (50% of dose) and a modified-release component (50% of dose). This is why Medikinet XL 10 mg yields an immediate-release dose of 5 mg and an extended-release dose of 5 mg¹.

The extended-release portion of each dose is designed to maintain a treatment response through the afternoon, without the need for a midday dose. This is designed to work with the school day, delivering therapeutic plasma levels for around 8 hours¹.

If adults are new to Medikinet^® XL (methylphenidate hydrochloride)

• At the beginning of treatment, careful dose titration is necessary, starting at the lowest possible dose¹
• Recommended starting daily dose is 10 mg daily, which may be increased, if necessary by weekly increments of 10 mg in the daily dose¹
• The total daily dose should be given in two divided doses in the morning and at midday. Medikinet XL has to be taken with or after a meal in order to obtain sufficiently prolonged action and to avoid high plasma peaks. Therefore, Medikinet XL should not be administered without food¹
• Compared to children and adolescents, adult patients may require a higher daily dose, based on patient’s body weight. The maximum daily dose must not exceed 1mg/kg body weight. Regardless of body weight, a maximum daily dose of 80mg should not be exceeded¹

Continuing therapy with Medikinet^® XL (methylphenidate hydrochloride) into adulthood

Adult patients who’ve shown clear benefit from treatment with Medikinet^® XL in childhood or adolescence may continue treatment into adulthood. Initially, this can be at the same daily dose (mg/day). Whether an adjustment is needed depends on how well it continues to work and its tolerability¹.

Safety and Monitoring

Access our full safety and monitoring information or please refer to section 4 of the SPC.