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Mellozzan® (melatonin) immediate-release tablets

Prescribing Information

Mellozzan® is indicated for insomnia in children and adolescents aged 6-17 years with Attention-Deficit Hyperactivity Disorder (ADHD), where sleep hygiene measures have been insufficient.1

Dosing & administration

  • Recommended starting dose of Mellozzan® tablets: 0.5–2 mg 30–60 minutes before bedtime1
  • The dose of melatonin can be increased by 1 mg every week until effect up to a maximum 5 mg per day, independent of age. The lowest effective dose should be sought1
  • The tablets can be crushed and mixed with water directly before the administration1

Food can enhance the increase in plasma melatonin concentration (see section 5.2 of SPC). Intake of melatonin with carbohydrate-rich meals may impair blood glucose control for several hours (see section 4.4 of SPC). It is recommended that food is not consumed 2 hours before and 2 hours after intake of Mellozzan® tablets, ideally at least 3 hours after a meal by persons with significantly impaired glucose tolerance or diabetes.1

Safety and Monitoring

Access our full safety and monitoring information or please refer to section 4 of the SPC.

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Date of Preparation: November 2025 UK-MEL-2025-2620-v1

Adverse event reporting
Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/ or search for MHRA Yellow Card in the Google Play or Apple App Store.
Adverse events should be reported to MEDICE UK, Medical Information Tel: 0204 582 2845, pv-uk@medice.co.uk